Current Scansite Motif Groups

The Scansite motifs included in each group definition are listed below.

Phosphoserine/threonine binding group (pST_bind)

14-3-3 Mode 1 (1433_m1)

Tyrosine kinase group (Y_kin)

Abl Kinase (Abl_Kin)
EGFR Kinase (EGFR_Kin)
Fgr Kinase (Fgr_Kin)
Insulin Receptor Kinase (InsR_Kin)
Itk Kinase (Itk_Kin)
Lck Kinase (Lck_Kin)
PDGFR Kin (PDGFR_Kin)
Src Kinase (Src_Kin)

Src homology 2 group (SH2)

Abl SH2 (Abl_SH2)
Crk SH2 (Crk_SH2)
Fgr SH2 (Fgr_SH2)
Fyn SH2 (Fyn_SH2)
Grb2 SH2 (Grb2_SH2)
Itk SH2 (Itk_SH2)
Lck SH2 (Lck_SH2)
Nck SH2 (Nck_SH2)
p85 SH2 (p85_SH2)
PLCg C-terminal SH2 (PLCg_CSH2)
PLCg N-terminal SH2 (PLCg_NSH2)
Shc SH2 (Shc_SH2)
SHIP SH2 (SHIP_SH2)
Src SH2 (Src_SH2)

Src homology 3 group (SH3)

Abl SH3 (Abl_SH3)
Amphiphysin SH3 (Amphi_SH3)
Cbl-Associated protein C-SH3 (CapC_SH3)
Cortactin SH3 (Cort_SH3)
Crk SH3 (Crk_SH3)
Grb2 SH3 (Grb2_SH3)
Intersectin SH3A (Itsn_SH3)
Itk SH3 (Itk_SH3)
Nck 2nd SH3 (Nck_2nd_SH3)
p85 SH3 mode1 (p85_SH3_m1)
p85 SH3 mode2 (p85_SH3_m2)
PLCg SH3 (PLCg_SH3)
Src SH3 (Src_SH3)

Basophilic serine/threonine kinase group (Baso_ST_kin)

Akt Kinase (Akt_Kin)
Calmodulin dependent Kinase 2 (Cam_Kin2)
Clk2 Kinase (Clk2_Kin)
Protein Kinase A (PKA_Kin)
PKC alpha/beta/gamma (PKC_common)
PKC delta (PKC_delta)
PKC epsilon (PKC_epsilon)
PKC mu (PKC_mu)
PKC zeta (PKC_zeta)
AMP_Kinase (AMPK)

DNA damage kinase group (DNA_dam_kin)

ATM Kinase (ATM_Kin)
DNA PK (DNA_PK)

Acidophilic serine/threonine kinase group (Acid_ST_kin)

Casein Kinase 1 (Casn_Kin1)
Casein Kinase 2 (Casn_Kin2)
GSK3 Kinase (GSK3_Kin)
GSK3-improved (GSK3b)

Proline-dependent serine/threonine kinase group (Pro_ST_kin)

Cdc2 Kinase (Cdc2_Kin)
Cdk5 Kinase (Cdk5_Kin)
Erk1 Kinase (Erk1_Kin)
p38 MAPK (p38_Kin)

Kinase binding site group (Kin_bind)

Erk1 Binding (Erk1_Bind)
PDK1 Binding (PDK1_Bind)
Erk D-domain (ErkDD)

PDZ domain binding group (PDZ)

PDZ class 1 (PDZ_class1)
PDZ class 2 (PDZ_class2)
PDZ (nNOS) class 1 (PDZ_nNOS_1)
PDZ (nNOS) class 3 (PDZ_nNOS_3)

Phosphotyrosine binding group (PTB)

Shc PTB (Shc_PTB)

Lipid binding group (Lip_bind)

PIP3-binding PH (PIP3_PH)